Human Lymphoblastoid CD4(+) T Cells Become Permissive to Macrophage-Tropic Strains of Human Immunodeficiency Virus Type 1 after Passage into Severe Combined Immunodeficient Mice through In Vivo Upregulation of CCR5: In Vivo Dynamics of CD4(+) T-Cell Differentiation in Pathogenesis of AIDS

In this article, we show that passage in SCID mice rendered a human CD4(+) T-cell line (CEM cells) highly susceptible to infection by macrophage-tropic (M-tropic) strains and primary clinical isolates of human immunodeficiency virus type 1 (HIV-1). This in vivo-acquired permissiveness of CEM cells w...

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Main Authors: Lapenta, Caterina, Parlato, Stefania, Spada, Massimo, Santini, Stefano M., Rizza, Paola, Logozzi, Mariantonia, Proietti, Enrico, Belardelli, Filippo, Fais, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC110622/
https://ncbi.nlm.nih.gov/pubmed/9811784
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