The African Swine Fever Virus Thymidine Kinase Gene Is Required for Efficient Replication in Swine Macrophages and for Virulence in Swine

African swine fever virus (ASFV) replicates in the cytoplasm of infected cells and contains genes encoding a number of enzymes needed for DNA synthesis, including a thymidine kinase (TK) gene. Recombinant TK gene deletion viruses were produced by using two highly pathogenic isolates of ASFV through...

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Main Authors: Moore, D. M., Zsak, L., Neilan, J. G., Lu, Z., Rock, D. L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Viral Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC110620/
https://ncbi.nlm.nih.gov/pubmed/9811782
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