Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells
The 55-kDa E1B protein of adenovirus, which binds to and inactivates the tumor suppressor protein p53, is not expressed in the adenoviral mutant termed ONYX-015 (i.e., dl1520). It was reported that the mutant virus due to a deletion in E1B is able to replicate only in cells deficient for wild-type p...
Spremljeno u:
| Izdano u: | J Virol |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Microbiology (ASM)
1998
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110441/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811680/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.12.9470-9478.1998 |
| Oznake: |
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|