Replication of ONYX-015, a Potential Anticancer Adenovirus, Is Independent of p53 Status in Tumor Cells

The 55-kDa E1B protein of adenovirus, which binds to and inactivates the tumor suppressor protein p53, is not expressed in the adenoviral mutant termed ONYX-015 (i.e., dl1520). It was reported that the mutant virus due to a deletion in E1B is able to replicate only in cells deficient for wild-type p...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Rothmann, Thomas, Hengstermann, Arnd, Whitaker, Noel J., Scheffner, Martin, zur Hausen, Harald
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1998
Materias:	Virus-Cell Interactions
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110441/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811680/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.12.9470-9478.1998
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