Limited Entry of Adenovirus Vectors into Well-Differentiated Airway Epithelium Is Responsible for Inefficient Gene Transfer

Investigations of the efficiency and safety of human adenovirus vector (AdV)-mediated gene transfer in the airways of patients with cystic fibrosis (CF) in vivo have demonstrated little success in correcting the CF bioelectrical functional defect, reflecting the inefficiency of AdV-mediated gene tra...

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Bibliographic Details
Main Authors: Pickles, Raymond J., McCarty, Douglas, Matsui, Hirotoshi, Hart, Pádraig J., Randell, Scott H., Boucher, Richard C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC110406/
https://ncbi.nlm.nih.gov/pubmed/9621064
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