Inhibition of NF-κB Activation in Combination with Bcl-2 Expression Allows for Persistence of First-Generation Adenovirus Vectors in the Mouse Liver

NF-κB is a key regulator of the innate antiviral immune response, due in part to its transcriptional activation of cytokines and adhesion molecules, which, in turn, function in chemotaxis and activation of inflammatory cells. We reported earlier that viral gene expression in hepatocytes transduced w...

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Autores principales: Lieber, André, He, Chen-Yi, Meuse, Leonard, Himeda, Charis, Wilson, Christopher, Kay, Mark A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1998
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC110346/
https://ncbi.nlm.nih.gov/pubmed/9765474
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