The Role of Interferon in Influenza Virus Tissue Tropism

We have studied the pathogenesis of influenza virus infection in mice that are unable to respond to type I or II interferons due to a targeted disruption of the STAT1 gene. STAT1−/− animals are 100-fold more sensitive to lethal infection with influenza A/WSN/33 virus than are their wild-type (WT) co...

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Bibliographic Details
Main Authors: García-Sastre, Adolfo, Durbin, Russell K., Zheng, Hongyong, Palese, Peter, Gertner, Rachel, Levy, David E., Durbin, Joan E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Viral Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC110265/
https://ncbi.nlm.nih.gov/pubmed/9765393
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