Nasal Immunization of Mice with Human Papillomavirus Type 16 Virus-Like Particles Elicits Neutralizing Antibodies in Mucosal Secretions

To specifically induce a mucosal antibody response to purified human papillomavirus type 16 (HPV16) virus-like particles (VLP), we immunized female BALB/c mice orally, intranasally, and/or parenterally and evaluated cholera toxin (CT) as a mucosal adjuvant. Anti-HPV16 VLP immunoglobulin G (IgG) and...

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Main Authors: Balmelli, Carole, Roden, Richard, Potts, Alexandra, Schiller, John, De Grandi, Pierre, Nardelli-Haefliger, Denise
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1998
Assuntos:
Viral Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC110174/
https://ncbi.nlm.nih.gov/pubmed/9733865
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