Mutations in the Primer Grip of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impair Proviral DNA Synthesis and Virion Maturation

This report describes the effects of mutating highly conserved residues in the primer grip domain of human immunodeficiency virus type 1 reverse transcriptase (RT) on virus formation and infectivity. Among a series of RT mutant viruses, three (M230A, L234D, and W239A) were found to be noninfectious...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Yu, Qiang, Ottmann, Michele, Pechoux, Christine, Le Grice, Stuart, Darlix, Jean-Luc
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Virus-Cell Interactions
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110040/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9696874/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.9.7676-7680.1998
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