Transient Inhibition of CD28 and CD40 Ligand Interactions Prolongs Adenovirus-Mediated Transgene Expression in the Lung and Facilitates Expression after Secondary Vector Administration

Recombinant adenovirus vectors have been used to transfer genes to the lungs in animal models, but the extent and duration of primary transgene expression and the ability to achieve expression after repeated vector administration have been limited by the development of antigen-specific immunity to t...

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Publié dans:	J Virol
Auteurs principaux:	Wilson, Christopher B., Embree, Lisa J., Schowalter, David, Albert, Richard, Aruffo, Alejandro, Hollenbaugh, Diane, Linsley, Peter, Kay, Mark A.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1998
Sujets:	Gene Therapy
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109997/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9696851/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.9.7542-7550.1998
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