DNA Vaccination Affords Significant Protection against Feline Immunodeficiency Virus Infection without Inducing Detectable Antiviral Antibodies

To test the potential of a multigene DNA vaccine against lentivirus infection, we generated a defective mutant provirus of feline immunodeficiency virus (FIV) with an in-frame deletion in pol (FIVΔRT). In a first experiment, FIVΔRT DNA was administered intramuscularly to 10 animals, half of which al...

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Détails bibliographiques
Auteurs principaux: Hosie, Margaret J., Flynn, J. Norman, Rigby, Mark A., Cannon, Celia, Dunsford, Thomas, Mackay, Nancy A., Argyle, David, Willett, Brian J., Miyazawa, Takayuki, Onions, David E., Jarrett, Oswald, Neil, James C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 1998
Sujets:
Viral Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC109955/
https://ncbi.nlm.nih.gov/pubmed/9696827
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