DNA Vaccination Affords Significant Protection against Feline Immunodeficiency Virus Infection without Inducing Detectable Antiviral Antibodies

To test the potential of a multigene DNA vaccine against lentivirus infection, we generated a defective mutant provirus of feline immunodeficiency virus (FIV) with an in-frame deletion in pol (FIVΔRT). In a first experiment, FIVΔRT DNA was administered intramuscularly to 10 animals, half of which al...

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Bibliographic Details
Main Authors: Hosie, Margaret J., Flynn, J. Norman, Rigby, Mark A., Cannon, Celia, Dunsford, Thomas, Mackay, Nancy A., Argyle, David, Willett, Brian J., Miyazawa, Takayuki, Onions, David E., Jarrett, Oswald, Neil, James C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1998
Subjects:
Viral Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC109955/
https://ncbi.nlm.nih.gov/pubmed/9696827
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