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The Epstein-Barr Virus Major Latent Promoter Qp Is Constitutively Active, Hypomethylated, and Methylation Sensitive

Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) is indispensable for viral DNA replication and episome maintenance in latency. Four promoters, Cp, Wp, Qp, and Fp, are known to drive EBNA1 expression. Here we show that the TATA-less Qp is constitutively active in a variety of EBV-positive [EBV(+)]...

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Udgivet i:J Virol
Principais autores: Tao, Qian, Robertson, Keith D., Manns, Angela, Hildesheim, Allan, Ambinder, Richard F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Animal Viruses
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109928/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9696800/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.9.7075-7083.1998
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