The Second-Site Mutation in the Herpes Simplex Virus Recombinants Lacking the γ(1)34.5 Genes Precludes Shutoff of Protein Synthesis by Blocking the Phosphorylation of eIF-2α
In cells infected with the herpes simplex virus 1 (HSV-1) recombinant R3616 lacking both copies of the γ(1)34.5 gene, the double-stranded protein kinase R (PKR) is activated, eIF-2α is phosphorylated, and protein synthesis is shut off. Although PKR is also activated in cells infected with the wild-t...
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| Publicado no: | J Virol |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109920/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9696792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.9.7005-7011.1998 |
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