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Transcription of the derepressed open reading frame P of herpes simplex virus 1 precludes the expression of the antisense gamma(1)34.5 gene and may account for the attenuation of the mutant virus.
Open reading frame P (ORF P), located at the 3' terminus of the 8.5-kb DNA sequence transcribed during latency and almost completely antisense to the gamma(1)34.5 gene, is naturally repressed by infected cell protein 4 (ICP4), the major herpes simplex virus 1 regulatory protein. Earlier studies...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
1997
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC192127/ https://ncbi.nlm.nih.gov/pubmed/9311860 |
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