Mutation of the Lck-Binding Motif of Tip Enhances Lymphoid Cell Activation by Herpesvirus Saimiri

The proline-rich SH3-binding (SH3B) motif of the tyrosine kinase-interacting protein (Tip) of herpesvirus saimiri (HVS) is required for binding to the cellular Src family kinase Lck. We constructed a mutant form of HVS in which prolines in the SH3B motif of Tip were altered to alanines. This mutant...

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Pubblicato in:	J Virol
Autori principali:	Duboise, S. Monroe, Lee, Heuiran, Guo, Jie, Choi, Joong-Kook, Czajak, Susan, Simon, Meredith, Desrosiers, Ronald C., Jung, Jae U.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Virus-Cell Interactions
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109695/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9525577/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.4.2607-2614.1998
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