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Human Immunodeficiency Virus (HIV) Envelope Binds to CXCR4 Independently of CD4, and Binding Can Be Enhanced by Interaction with Soluble CD4 or by HIV Envelope Deglycosylation

Chemokine receptor CXCR4 (also known as LESTR and fusin) has been shown to function as a coreceptor for T-cell-tropic strains of human immunodeficiency virus type 1 (HIV-1). We have developed a binding assay to show that HIV envelope (Env) can interact with CXCR4 independently of CD4 but that this b...

Ausführliche Beschreibung

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Veröffentlicht in:J Virol
Hauptverfasser: Bandres, Juan C., Wang, Qing F., O’Leary, Jeanne, Baleaux, Françoise, Amara, Ali, Hoxie, James A., Zolla-Pazner, Susan, Gorny, Miroslaw K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 1998
Schlagworte:
Virus-Cell Interactions
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109552/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9499113/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.3.2500-2504.1998
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