Application of a Fas Ligand Encoding a Recombinant Adenovirus Vector for Prolongation of Transgene Expression

An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene e...

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Bibliographic Details
Main Authors: Zhang, Huang-Ge, Bilbao, Guadalupe, Zhou, Tong, Contreras, Juan Luis, Gómez-Navarro, Jesús, Feng, Meizhen, Saito, Izumu, Mountz, John D., Curiel, David T.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Gene Therapy
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC109549/
https://ncbi.nlm.nih.gov/pubmed/9499110
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