Immune Response to Recombinant Capsid Proteins of Adenovirus in Humans: Antifiber and Anti-Penton Base Antibodies Have a Synergistic Effect on Neutralizing Activity

Replication-deficient adenovirus used in humans for gene therapy induces a strong immune response to the vector, resulting in transient recombinant protein expression and the blocking of gene transfer upon a second administration. Therefore, in this study we examined in detail the capsid-specific hu...

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Vydáno v:	J Virol
Hlavní autoři:	Gahéry-Ségard, Hanne, Farace, Françoise, Godfrin, Dominique, Gaston, Jesintha, Lengagne, Renée, Tursz, Thomas, Boulanger, Pierre, Guillet, Jean-Gérard
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 1998
Témata:	Viral Pathogenesis and Immunity
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109538/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9499099/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.3.2388-2397.1998
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