Construction and Characterization of a Temperature-Sensitive Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant

A temperature-sensitive (ts) human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutant was generated by charged-cluster-to-alanine mutagenesis. The mutant virus, containing three charged residues within the RT finger domain changed to alanine (K64A, K66A, and D67A), replicated no...

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Bibliografiska uppgifter
Huvudupphovsmän: Huang, Mingjun, Zensen, Ralf, Cho, Michael, Martin, Malcolm A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 1998
Ämnen:
Animal Viruses
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC109498/
https://ncbi.nlm.nih.gov/pubmed/9499059
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