Characterization of Replication-Competent Hepatitis A Virus Constructs Containing Insertions at the N Terminus of the Polyprotein

To determine whether hepatitis A virus (HAV) could tolerate the insertion of exogenous sequences, we constructed full-length HAV cDNAs containing in-frame insertions at the N terminus of the polyprotein and transfected the derived T7 RNA polymerase in vitro transcripts into FRhK-4 cells. Replication...

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Bibliographic Details
Main Authors: Zhang, Yuan, Kaplan, Gerardo G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Animal Viruses
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC109382/
https://ncbi.nlm.nih.gov/pubmed/9420233
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