Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 Entry

The CC-chemokine receptor CCR5 is required for the efficient fusion of macrophage (M)-tropic human immunodeficiency virus type 1 (HIV-1) strains with the plasma membrane of CD4(+) cells and interacts directly with the viral surface glycoprotein gp120. Although receptor chimera studies have provided...

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Detalhes bibliográficos
Main Authors: Dragic, Tatjana, Trkola, Alexandra, Lin, Steven W., Nagashima, Kirsten A., Kajumo, Francis, Zhao, Lu, Olson, William C., Wu, Lijun, Mackay, Charles R., Allaway, Graham P., Sakmar, Thomas P., Moore, John P., Maddon, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC109374/
https://ncbi.nlm.nih.gov/pubmed/9420225
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