Interaction of Glycogen Synthase Kinase 3β with the DF3/MUC1 Carcinoma-Associated Antigen and β-Catenin

The DF3/MUC1 mucin-like glycoprotein is highly overexpressed in human carcinomas. Recent studies have demonstrated that the cytoplasmic domain of MUC1 interacts with β-catenin. Here we show that MUC1 associates with glycogen synthase kinase 3β (GSK3β). GSK3β binds directly to an STDRSPYE site in MUC...

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Bibliographic Details
Main Authors: Li, Yongqing, Bharti, Ajit, Chen, Dongshu, Gong, Jianlin, Kufe, Donald
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC109303/
https://ncbi.nlm.nih.gov/pubmed/9819408
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