p21(WAF1/CIP1) Is Upregulated by the Geranylgeranyltransferase I Inhibitor GGTI-298 through a Transforming Growth Factor β- and Sp1-Responsive Element: Involvement of the Small GTPase RhoA

We have recently reported that the geranylgeranyltransferase I inhibitor GGTI-298 arrests human tumor cells at the G(1) phase of the cell cycle and increases the protein and RNA levels of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1). Here, we show that GGTI-298 acts at the transcriptional le...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Adnane, Jalila, Bizouarn, Francisco A., Qian, Yimin, Hamilton, Andrew D., Sebti, Saïd M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1998
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109279/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9819384/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.12.6962
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