High-Level Expression of Marek's Disease Virus Glycoprotein C Is Detrimental to Virus Growth In Vitro

Expression levels of Marek's disease virus (MDV) glycoprotein C (gC) are significantly reduced after serial virus passage in cell culture. Reduced gC expression coincides with enhanced MDV growth in vitro and attenuation. To analyze this phenomenon in detail, a full-length infectious MDV clone...

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Main Authors: Tischer, B. Karsten, Schumacher, Daniel, Chabanne-Vautherot, Danièlle, Zelnik, Vladimir, Vautherot, Jean-François, Osterrieder, Nikolaus
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091721/
https://ncbi.nlm.nih.gov/pubmed/15857974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.10.5889-5899.2005
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