Evaluation of Human Monoclonal Antibody 80R for Immunoprophylaxis of Severe Acute Respiratory Syndrome by an Animal Study, Epitope Mapping, and Analysis of Spike Variants

In this report, the antiviral activity of 80R immunoglobulin G1 (IgG1), a human monoclonal antibody against severe acute respiratory syndrome coronavirus (SARS-CoV) spike (S) protein that acts as a viral entry inhibitor in vitro, was investigated in vivo in a mouse model. When 80R IgG1 was given pro...

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Detalhes bibliográficos
Main Authors: Sui, Jianhua, Li, Wenhui, Roberts, Anjeanette, Matthews, Leslie J., Murakami, Akikazu, Vogel, Leatrice, Wong, Swee Kee, Subbarao, Kanta, Farzan, Michael, Marasco, Wayne A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091676/
https://ncbi.nlm.nih.gov/pubmed/15857975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.10.5900-5906.2005
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