Evaluation of Human Monoclonal Antibody 80R for Immunoprophylaxis of Severe Acute Respiratory Syndrome by an Animal Study, Epitope Mapping, and Analysis of Spike Variants

In this report, the antiviral activity of 80R immunoglobulin G1 (IgG1), a human monoclonal antibody against severe acute respiratory syndrome coronavirus (SARS-CoV) spike (S) protein that acts as a viral entry inhibitor in vitro, was investigated in vivo in a mouse model. When 80R IgG1 was given pro...

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Hlavní autoři: Sui, Jianhua, Li, Wenhui, Roberts, Anjeanette, Matthews, Leslie J., Murakami, Akikazu, Vogel, Leatrice, Wong, Swee Kee, Subbarao, Kanta, Farzan, Michael, Marasco, Wayne A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2005
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091676/
https://ncbi.nlm.nih.gov/pubmed/15857975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.10.5900-5906.2005
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