Exploiting cis-Acting Replication Elements To Direct Hepatitis C Virus-Dependent Transgene Expression

We describe here a novel targeting gene therapy strategy to direct gene expression responsive to hepatitis C virus (HCV). The goal was approached by engineering a construct containing the antisense sequence of the transgene and internal ribosome entry site of encephalomyocarditis virus flanked by 5′...

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Detalhes bibliográficos
Main Authors: Zhang, Jing, Yamada, Osamu, Sakamoto, Takashi, Yoshida, Hiroshi, Araki, Hiromasa, Shimotohno, Kunitada
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091670/
https://ncbi.nlm.nih.gov/pubmed/15857978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.10.5923-5932.2005
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