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Immunization with the Gene Expressing Woodchuck Hepatitis Virus Nucleocapsid Protein Fused to Cytotoxic-T-Lymphocyte-Associated Antigen 4 Leads to Enhanced Specific Immune Responses in Mice and Woodchucks

A number of options are available to modify and improve DNA vaccines. An interesting approach to improve DNA vaccines is to fuse bioactive domains, like cytotoxic-T-lymphocyte-associated protein 4 (CTLA-4), to an antigen. Such fusion antigens are expressed in vivo and directed to immune cells by the...

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Autori principali: Lu, Mengji, Isogawa, Masanori, Xu, Yang, Hilken, Gero
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091665/
https://ncbi.nlm.nih.gov/pubmed/15858020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.10.6368-6376.2005
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