Regulation of Mdm2-Directed Degradation by the C Terminus of p53
The stability of the p53 tumor suppressor protein is regulated by interaction with Mdm2, the product of a p53-inducible gene. Mdm2-targeted degradation of p53 depends on the interaction between the two proteins and is mediated by the proteasome. We show here that in addition to the N-terminal Mdm2 b...
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| Publicado no: | Mol Cell Biol |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109155/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9742086/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.10.5690 |
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