The Ability of CD40L, but Not Lipopolysaccharide, To Initiate Immunoglobulin Switching to Immunoglobulin G1 Is Explained by Differential Induction of NF-κB/Rel Proteins

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not by lipopolysaccharide (LPS). CD40 engagement contributes to this preferential isotype production by activating NF-κB/Rel to induce germ line γ1 transcripts, which are essential for class switch recombi...

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Bibliografische gegevens

Gepubliceerd in:	Mol Cell Biol
Hoofdauteurs:	Lin, Shih-Chang, Wortis, Henry H., Stavnezer, Janet
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Taylor & Francis 1998
Onderwerpen:	Transcriptional Regulation
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109137/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9710636/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.9.5523
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