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The Ability of CD40L, but Not Lipopolysaccharide, To Initiate Immunoglobulin Switching to Immunoglobulin G1 Is Explained by Differential Induction of NF-κB/Rel Proteins

Antibodies of the immunoglobulin G1 class are induced in mice by T-cell-dependent antigens but not by lipopolysaccharide (LPS). CD40 engagement contributes to this preferential isotype production by activating NF-κB/Rel to induce germ line γ1 transcripts, which are essential for class switch recombi...

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Udgivet i:Mol Cell Biol
Principais autores: Lin, Shih-Chang, Wortis, Henry H., Stavnezer, Janet
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1998
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109137/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9710636/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.9.5523
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