Control of PKR Protein Kinase by Hepatitis C Virus Nonstructural 5A Protein: Molecular Mechanisms of Kinase Regulation

The PKR protein kinase is a critical component of the cellular antiviral and antiproliferative responses induced by interferons. Recent evidence indicates that the nonstructural 5A (NS5A) protein of hepatitis C virus (HCV) can repress PKR function in vivo, possibly allowing HCV to escape the antivir...

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Detalhes bibliográficos
Main Authors: Gale, Michael, Blakely, Collin M., Kwieciszewski, Bart, Tan, Seng-Lai, Dossett, Michelle, Tang, Norina M., Korth, Marcus J., Polyak, Stephen J., Gretch, David R., Katze, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC109106/
https://ncbi.nlm.nih.gov/pubmed/9710605
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