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Deregulation of Poly(A) Polymerase Interferes with Cell Growth

Vertebrate poly(A) polymerase (PAP) contains a catalytic domain and a C-terminal Ser-Thr-rich regulatory region. Consensus and nonconsensus cyclin-dependent kinase (cdk) sites are conserved in the Ser-Thr-rich region in vertebrate PAPs. PAP is phosphorylated by cdc2-cyclin B on these sites in vitro...

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Detalhes bibliográficos
Main Authors: Zhao, Wenqing, Manley, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC109086/
https://ncbi.nlm.nih.gov/pubmed/9710585
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