Functional Analysis of Coordinated Cleavage in V(D)J Recombination
V(D)J recombination in vivo requires a pair of signals with distinct spacer elements of 12 and 23 bp that separate conserved heptamer and nonamer motifs. Cleavage in vitro by the RAG1 and RAG2 proteins can occur at individual signals when the reaction buffer contains Mn(2+), but cleavage is restrict...
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| Publicado en: | Mol Cell Biol |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
1998
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109054/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671478/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.8.4679 |
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