Normal Myeloid Development Requires Both the Glutamine-Rich Transactivation Domain and the PEST Region of Transcription Factor PU.1 but Not the Potent Acidic Transactivation Domain

Gene targeting of transcription factor PU.1 results in an early block to fetal hematopoiesis, with no detectable lymphoid or myeloid cells produced in mouse embryos. Furthermore, PU.1(−/−) embryonic stem (ES) cells fail to differentiate into Mac-1(+) and F4/80(+) macrophages in vitro. We have previo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fisher, Robert C., Olson, Marilyn C., Pongubala, Jagan M. R., Perkel, Jeffrey M., Atchison, Michael L., Scott, Edward W., Simon, M. Celeste
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 1998
Pynciau:
Transcriptional Regulation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC109018/
https://ncbi.nlm.nih.gov/pubmed/9632818
Tagiau: Ychwanegu Tag
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