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Normal Myeloid Development Requires Both the Glutamine-Rich Transactivation Domain and the PEST Region of Transcription Factor PU.1 but Not the Potent Acidic Transactivation Domain

Gene targeting of transcription factor PU.1 results in an early block to fetal hematopoiesis, with no detectable lymphoid or myeloid cells produced in mouse embryos. Furthermore, PU.1(−/−) embryonic stem (ES) cells fail to differentiate into Mac-1(+) and F4/80(+) macrophages in vitro. We have previo...

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Udgivet i:Mol Cell Biol
Principais autores: Fisher, Robert C., Olson, Marilyn C., Pongubala, Jagan M. R., Perkel, Jeffrey M., Atchison, Michael L., Scott, Edward W., Simon, M. Celeste
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1998
Fag:
Transcriptional Regulation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109018/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9632818/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.7.4347
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