Cytoplasmic Sequestration of the Polyomavirus Enhancer Binding Protein 2 (PEBP2)/Core Binding Factor α (CBFα) Subunit by the Leukemia-Related PEBP2/CBFβ-SMMHC Fusion Protein Inhibits PEBP2/CBF-Mediated Transactivation

The polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor (CBF) is a transcription factor composed of two subunits, α and β. The gene encoding the β subunit is disrupted by inv(16), resulting in the formation of a chimeric protein, β-SMMHC, which is associated with acute myelogenous le...

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Dettagli Bibliografici
Autori principali: Kanno, Yuka, Kanno, Tomohiko, Sakakura, Chohei, Bae, Suk-Chul, Ito, Yoshiaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1998
Soggetti:
Transcriptional Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC109009/
https://ncbi.nlm.nih.gov/pubmed/9632809
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