The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils

The cytoplasmic protein tyrosine kinase Syk has two amino-terminal SH2 domains that engage phosphorylated immunoreceptor tyrosine-based activation motifs in the signaling subunits of immunoreceptors. Syk, in conjunction with Src family kinases, has been implicated in immunoreceptor signaling in both...

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Bibliographic Details
Main Authors: Kiefer, Friedemann, Brumell, John, Al-Alawi, Nadia, Latour, Sylvain, Cheng, Alec, Veillette, André, Grinstein, Sergio, Pawson, Tony
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC109005/
https://ncbi.nlm.nih.gov/pubmed/9632805
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