Analysis of Gene Targeting and Intrachromosomal Homologous Recombination Stimulated by Genomic Double-Strand Breaks in Mouse Embryonic Stem Cells

To investigate the effects of in vivo genomic DNA double-strand breaks on the efficiency and mechanisms of gene targeting in mouse embryonic stem cells, we have used a series of insertion and replacement vectors carrying two, one, or no genomic sites for the rare-cutting endonuclease I-SceI. These v...

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Detaylı Bibliyografya

Yayımlandı:	Mol Cell Biol
Asıl Yazarlar:	Donoho, Greg, Jasin, Maria, Berg, Paul
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Taylor & Francis 1998
Konular:	DNA Dynamics and Chromosome Structure
Online Erişim:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108991/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9632791/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.7.4070
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