Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation

FRS2 is a lipid-anchored docking protein that plays an important role in linking fibroblast growth factor (FGF) and nerve growth factor receptors with the Ras/mitogen-activated protein (MAP) kinase signaling pathway. In this report, we demonstrate that FRS2 forms a complex with the N-terminal SH2 do...

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Bibliographic Details
Main Authors: Hadari, Y. R., Kouhara, H., Lax, I., Schlessinger, J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC108981/
https://ncbi.nlm.nih.gov/pubmed/9632781
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