Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line

T-cell antigen receptor (TCR) engagement activates multiple protein tyrosine kinases (PTKs), including the Src family member, Lck, and the Syk-related PTK, ZAP-70. Studies in ZAP-70-deficient humans have demonstrated that ZAP-70 plays crucial roles in T-cell activation and development. However, prog...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Williams, Brandi L., Schreiber, Kathy L., Zhang, Weiguo, Wange, Ronald L., Samelson, Lawrence E., Leibson, Paul J., Abraham, Robert T.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1998
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108852/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9488454/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.18.3.1388
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