Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line

T-cell antigen receptor (TCR) engagement activates multiple protein tyrosine kinases (PTKs), including the Src family member, Lck, and the Syk-related PTK, ZAP-70. Studies in ZAP-70-deficient humans have demonstrated that ZAP-70 plays crucial roles in T-cell activation and development. However, prog...

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Detalhes bibliográficos
Main Authors: Williams, Brandi L., Schreiber, Kathy L., Zhang, Weiguo, Wange, Ronald L., Samelson, Lawrence E., Leibson, Paul J., Abraham, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC108852/
https://ncbi.nlm.nih.gov/pubmed/9488454
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