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Synonymous mutations in CFTR exon 12 affect splicing and are not neutral in evolution
It is well established that exonic sequences contain regulatory elements of splicing that overlap with coding capacity. However, the conflict between ensuring splicing efficiency and preserving the coding capacity for an optimal protein during evolution has not been specifically analyzed. In fact, s...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1088389/ https://ncbi.nlm.nih.gov/pubmed/15840711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502288102 |
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