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Gain-of-function amino acid substitutions drive positive selection of FGFR2 mutations in human spermatogonia
Despite the importance of mutation in genetics, there are virtually no experimental data on the occurrence of specific nucleotide substitutions in human gametes. C>G transversions at position 755 of FGF receptor 2 (FGFR2) cause Apert syndrome; this mutation, encoding the gain-of-function substitu...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2005
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1087921/ https://ncbi.nlm.nih.gov/pubmed/15840724 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500267102 |
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