A mutation in T7 RNA polymerase that facilitates promoter clearance

Like multisubunit RNA polymerases (RNAPs), T7 RNAP frequently releases its transcript over the initial 8-12 transcribed nucleotides, when it still contacts the promoter. This abortive cycling, which is most prominent with initial sequences that deviate from those of T7 late genes, eventually comprom...

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Bibliographic Details
Main Authors: Guillerez, Jean, Lopez, Pascal J., Proux, Florence, Launay, Hélène, Dreyfus, Marc
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087904/
https://ncbi.nlm.nih.gov/pubmed/15831591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407141102
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