A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models

BACKGROUND: G- Protein coupled receptors (GPCRs) comprise the largest group of eukaryotic cell surface receptors with great pharmacological interest. A broad range of native ligands interact and activate GPCRs, leading to signal transduction within cells. Most of these responses are mediated through...

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Main Authors: Sgourakis, Nikolaos G, Bagos, Pantelis G, Papasaikas, Panagiotis K, Hamodrakas, Stavros J
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2005
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087828/
https://ncbi.nlm.nih.gov/pubmed/15847681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-6-104
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