Targeted Disruption of the Mn1 Oncogene Results in Severe Defects in Development of Membranous Bones of the Cranial Skeleton

Fusion of the MN1 gene to TEL (ETV6) results in myeloid leukemia. The fusion protein combines the transcription activating domain of MN1 and the DNA binding domain of TEL and is thought to act as a deranged transcription factor. In addition, disruption of the large first exon of the MN1 gene is thou...

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Päätekijät: Meester-Smoor, Magda A., Vermeij, Marcel, van Helmond, Marjolein J. L., Molijn, Anco C., van Wely, Karel H. M., Hekman, Arnold C. P., Vermey-Keers, Christl, Riegman, Peter H. J., Zwarthoff, Ellen C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2005
Aiheet:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087735/
https://ncbi.nlm.nih.gov/pubmed/15870292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.10.4229-4236.2005
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