Chromatin Inactivation Precedes De Novo DNA Methylation during the Progressive Epigenetic Silencing of the RASSF1A Promoter

Epigenetic inactivation of the RASSF1A tumor suppressor by CpG island methylation was frequently detected in cancer. However, the mechanisms of this aberrant DNA methylation are unknown. In the RASSF1A promoter, we characterized four Sp1 sites, which are frequently methylated in cancer. We examined...

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Detalhes bibliográficos
Main Authors: Strunnikova, Maria, Schagdarsurengin, Undraga, Kehlen, Astrid, Garbe, James C., Stampfer, Martha R., Dammann, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087733/
https://ncbi.nlm.nih.gov/pubmed/15870267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.10.3923-3933.2005
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