Vav Activation and Function as a Rac Guanine Nucleotide Exchange Factor in Macrophage Colony-Stimulating Factor-Induced Macrophage Chemotaxis

Signal transduction mediated by phosphatidylinositol 3-kinase (PI 3-kinase) is regulated by hydrolysis of its products, a function performed by the 145-kDa SH2 domain-containing inositol phosphatase (SHIP). Here, we show that bone marrow macrophages of SHIP(−/−) animals have elevated levels of phosp...

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Autores principales: Vedham, Vidya, Phee, Hyewon, Coggeshall, K. Mark
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087731/
https://ncbi.nlm.nih.gov/pubmed/15870290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.10.4211-4220.2005
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